Here are three perspectives that I have found useful during my career:

"What we observe is not nature itself, but nature exposed to our method of questioning"

                                                                                            ...Werner Heisenberg, Nobel Laureate in Physics

and

"When you have eliminated the impossible, whatever remains, however improbable, must be the truth"

                                                                    ...Sir Arthur Conan Doyle (Sherlock Holmes) in The Sign of Four

and

 "When we try to pick out anything by itself, we find it hitched to everything else in the Universe."

                                                ...John Muir, My First Summer in the Sierra, Houghton Mifflin, Boston, 1911)